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Improving primary care diagnosis and classification of dengue fever with bedside ultrasound

Key Contact: Jonathan Kirsch

Activity Dates: 2018 to 2019

Country(ies): Colombia

Contact Information

Activity Description

The incidence of dengue virus (DENV) infection has increased dramatically throughout much of the world over the past few decades, and, among arboviral diseases, causes the highest burden of human morbidity and mortality. We hypothesize that portable ultrasound will help classify and risk-stratify DENV-infected patients beyond the standard clinical evaluation by identifying early plasma leakage.

Specific Aim 1: To describe ultrasound findings in patients in Colombia with suspected dengue fever by clinical phase and fever day, including novel measurements like pulmonary B-lines.

Specific Aim 2: To establish the prevalence, clinical meaning, and factors associated with plasma leakage in suspected dengue fever patients attending ambulatory health care services in an endemic area in Colombia.

Specific Aim 3: To determine if trained researchers can reliably perform bedside ultrasound and thus aid in the correct classification of dengue severity.

This study is eligible for CGHSR Scholar applications. Students should inquire with Dr. Kirsch and submit applications through

Activity Types

Education/Training, Research

Academic Health Center Units

Medical School
     Department of Medicine

Other Academic Health Center Units
     Center for Global Health and Social Responsibility (CGHSR)

Other Collaborators

Co-Principal Investigator:
Lyda Osorio, MD PhD, Associated Professor, Universidad del Valle (UniValle), Escuela de Salud Pública, Cali, Colombia

Katie B Anderson, MD PhD MSPH CTropMed, University of Minnesota Medical School
Stephen Dunlop MD, MPH, CTropMed, FACEP, Hennepin County Medical Center & University of Minnesota Medical School

Partner Organizations

Universidad del Valle (UniValle), Escuela de Salud Pública, Cali, Colombia


UMN CGHSR Global Health Seed Grant (2018)

Activity Topics

Infectious Disease, Zoonotic Disease

Special Tags

CGHSR Scholars